Grids, along with visual hierarchy, typography, color theory, rhythm, etc., are the basic foundations of design and yet they are widely ignored by the industry.
What do houses and well designed pages have in common? They are both built on a framework — a carefully measured, solid structure that forms a foundation on which to build.
Blueprint is a CSS framework that gives you a solid CSS foundation to build your project on top of, with an easy-to-use grid, sensible typography, and even a stylesheet for printing.
Beautiful portfolio site by Sarah France with a well designed six column grid system.